ABSTRACT In the last 40 years, since Irie and his coworkers began their study on the chemical constituents of red algal genus Laurencia (Rhodomelaceae, Ceramiales), numerous marine natural products chemists have reported varieties of halogenated secondary metabolites, particularly terpenoids and C15 acetogenins that are not encountered in any terrestrial organisms. This review describes the distributions, diversity in chemical structures, chemotaxonomical significance, Laurencia vs. Aplysia, and the biological and pharmacological activities of halogenated metabolites isolated from members of the genus Laurencia from Japanese waters.
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