ABSTRACT In the last decade, pincer-type palladacycles, this is palladium complexes containing tridentate ligands, have turned from mere curiosity to a very promising research topic. An outstanding balance between stability and reactivity enables them to promote several organic transformations. Among them, due to their great synthetic value, cross-coupling methodologies such as Suzuki, Stille, Heck or Hiyama reactions are the usually employed to evaluate the catalytic efficacy of a new pincer palladacycle. To date, symmetric pincer complexes have been the most commonly employed. However, the introduction of a desymmetrization element in the pincer core, and the subsequent effect in the catalytic behaviour have emerged as interesting research topics. In this report the applications of unsymmetric pincer complexes to promote cross-coupling reactions are compiled.
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