In Mexico, the species of Valeriana are known as “hierba del gato”, “raíz de gato”, “batata” and “cuitlamotli”. Valeriana edulis subsp. procera known as “Valeriana mexicana” is an endemic plant restricted to the central zone of México, widely used by traditional healers and the native population as a sedative and hypnotic remedy. The continual demand of its root has motivated its relative depletion. This paper reviews the studies accomplished by our research team concerning the clinical effects in human subjects of a standardized  hydroalcoholic extract from the roots and rhizomes of this endangered medicinal plant, as well as the correlation of the degree of differentiation and valepotriate content between  in vitro regenerated  and wild plants.