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Trends in Heterocyclic Chemistry   Volumes    Volume 8 
Abstract
Recent advances in the chemistry of 6-aryl-5-substituted-3(2H)-pyridazinones
Eddy Sotelo, Enrique Ravina
Pages: 113 - 125
Number of pages: 13
Trends in Heterocyclic Chemistry
Volume 8 

Copyright © 2002 Research Trends. All rights reserved

ABSTRACT

The present review covers the advances in the chemistry of 6-aryl-5-substituted- 3(2H)-pyridazinones made in our group during our search for new antiplatelet agents. As part of this project we have developed a number of different, useful synthetic pathways that have allowed the preparation of a wide range of 6-aryl-5-substituted- 3(2H)-pyridazinones. Our systematic studies on this series of compounds have led to the development of new and efficient procedures based on the use of the appropriate 5-substituted-6-phenyl-3(2H)-pyridazinones as star-ting materials in the preparation of 6-phenyl-4,5-substituted-3(2H)-pyridazinones.

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