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Current Topics in Biotechnology   Volumes    Volume 8 
Defense strategies for removing a highly toxic intermediate of glycerol reductive metabolism in Klebsiella pneumoniae
Jeong-Woo Seo, Lian Hua Luo, Baek-Rock Oh, Sun-Yeon Heo, Won-Kyung Hong, Ji-Young Kang, Chul Ho Kim
Pages: 35 - 38
Number of pages: 4
Current Topics in Biotechnology
Volume 8 

Copyright © 2014 Research Trends. All rights reserved

Klebsiella pneumoniae is known to have evolved two mechanisms for preventing accumulation of the highly toxic intermediate 3-hydroxypropion aldehyde during reductive glycerol metabolism in which the toxic intermediate is converted to 3-hydroxypropionic acid (3-HP). One metabolic pathway, which involves a propanediol-utilization protein (PduP), is important under late-stage growth conditions at which concentrations of 1,3-propanediol are high. The other is a non-specific mechanism that removes intracellular toxic aldehyde molecules by reactions catalyzed by various aldehyde dehydrogenases. These microbial metabolic pathways could find application in industry for the synthesis of 3-HP, which is a useful platform chemical.
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