Klebsiella pneumoniae is known to have evolved two mechanisms for preventing accumulation of the highly toxic intermediate 3-hydroxypropion aldehyde during reductive glycerol metabolism in which the toxic intermediate is converted to 3-hydroxypropionic acid (3-HP). One metabolic pathway, which involves a propanediol-utilization protein (PduP), is important under late-stage growth conditions at which concentrations of 1,3-propanediol are high. The other is a non-specific mechanism that removes intracellular toxic aldehyde molecules by reactions catalyzed by various aldehyde dehydrogenases. These microbial metabolic pathways could find application in industry for the synthesis of 3-HP, which is a useful platform chemical.
View Full Article