Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Trends in Developmental Biology   Volumes    Volume 8 
Abstract
Genetic deletion of Sirt1 results in a Kallmann syndrome phenotype in mice due to defective GnRH neuronal migration
Gabriele Di Sante, Mathew C. Casimiro, Timothy G. Pestell, Ismail Yaman, Agnese Di Rocco, Richard G. Pestell
Pages: 47 - 53
Number of pages: 7
Trends in Developmental Biology
Volume 8 

Copyright © 2014 Research Trends. All rights reserved

ABSTRACT
 
Sirt1 gene encodes an NAD+-dependent histone deacetylase. Hypogonadotropic hypogonadism is associated with energy restriction or may be inherited as congenital hypogonadotropic hypogonadism (CHH). CHH associated with a loss in sense of smell (anosmia) is called Kallmann syndrome. Kallmann syndrome is also associated with mutations in a group of genes that impact FGF8 function. In the recent studies by Di Sante et al., Sirt1-/- mice showed a hypogonadotropic hypogonadism due to failed gonadotropin-releasing hormone neuronal migration (GnRH). The Sirt1 catalytic function was required for GnRH neuronal migration via binding and deacetylating cortactin in an FGF8/FGFR1-dependent manner. The effect of Sirt1 on the hormonal status of Sirt1-/- mice, mediated via defective GnRH neuronal migration, links energy metabolism directly to the hypogonadal state. This review focuses on the biological function of Sirt1 in the brain and the mechanism by which Sirt1 promotes GnRH neuronal migration into the brain from the vomeronasal organ to the forebrain and how the failure of this migration leads to the development of Kallmann syndrome.
View Full Article  


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms