Ierobina is a Brazilian phytopharmaceutical product used in the treatment of dyspepsia. Despite its widespread use in the country for over 75 years, only recently has its therapeutic efficacy been attested in animals; however, to date, no toxicological investigations have been carried out for this product. The present work seeks to evaluate the chronic toxicity of Ierobina administrated by gavage in rabbits, after product administration per os daily, at the doses of 2800 mg/Kg for 180 days. The product presented a low chronic toxicity; all observed alterations were reversible; and no animal died during the experiments. However, histological evaluations of the kidney, liver and other selected organs showed normal architecture, suggesting no morphological disturbances. Hence, considering the obtained results and the fact that Ierobina has been commercialized for decades in Brazil, with no reported cases of toxicity, the product appears to be safe for human use.