Phosphoinositide 3-kinases regulate numerous intracellular signals and essential biological processes; defects in their expression or regulation are implicated in diverse pathologies. For these reasons, research efforts have focused on generating inhibitors of the catalytic activity of these proteins. Recent evidence nonetheless indicates important non-catalytic properties for these kinases. These kinase-independent roles include a scaffold function in the organization of complexes with other proteins or with DNA, which suggests that pharmacological inhibition of phosphoinositide 3-kinase activity will not always result in loss of function.
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