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Current Topics in Steroid Research   Volumes    Volume 9 
The role of ERα-36 in regulation of cell function
Yong-Qing Hua, Lena Sahlin
Pages: 83 - 91
Number of pages: 9
Current Topics in Steroid Research
Volume 9 

Copyright © 2012 Research Trends. All rights reserved

ERα-36, a newly described variant of the estrogen receptor alpha (ERα), is widely expressed in normal and tumor tissues. However, the functions of ERα-36 expression have not been fully revealed. ERα-36 is primarily localized to the plasma membrane and cytoplasm and has been shown to play a role in mediating non-genomic estrogen signaling. It has been demonstrated that ERα-36 is involved in cell differentiation, which could imply a key role in e.g. cancer development, nerve differentiation and immune cell maturation. Here we present a review of the recent findings in the field, especially in relation to breast cancer and the immune system, as well as the other ERs.
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