Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Trends in Neurology   Volumes    Volume 9 
Abstract
Neuroprotection with the red pepper agent capsaicin
Genevieve M. Fong, Shane Antao, Adrina Varda, Joanne M. Dennis, Paul K. Witting
Pages: 97 - 109
Number of pages: 13
Current Trends in Neurology
Volume 9 

Copyright © 2015 Research Trends. All rights reserved

ABSTRACT
 
Capsaicin has a long history of anecdotal benefit for counteracting pain, heat and itch, and a majority of research into its clinical application has focussed on its analgesic potential. However, capsaicin elicits several distinct cellular activities in addition to analgesia. Hence its therapeutic potential is being actively explored in a wide range of acute and chronic pathologies including stroke and neurodegeneration, inflammatory disease and sepsis, gastrointestinal disorders and cancer. Capsaicin generates cellular responses via its physiological receptor, the transient receptor potential cation channel subfamily V member 1 (TRPV1). TRPV1 are polymodal receptors present in both peripheral nerves and the central nervous system. They primarily function as sensors of noxious stimuli, such as heat, acid and pro-inflammatory molecules, and may play an important role in body temperature regulation. Activation of TRPV1 by capsaicin can sensitise sensory neurones or modulate nerve sensation and function to produce analgesia. Interestingly, capsaicin can also exert paradoxical actions on inflammatory processes, cell viability and vascular tone. These cellular activities are largely mediated via agonism of TRPV1 that elicits multiple effects including receptor activation to desensitisation and dysfunction through Ca2+-dependent processes. Capsaicin’s ability to reduce neuron excitation and activation is thought to be the basis of its therapeutic benefit in pain perception and other forms of neuroprotection associated with TRPV1. However, capsaicin has several cellular effects that show benefit including anti-inflammation, anti-oxidation and anti-proliferation and some of these actions are independent of neurones and TRPV1. Hence, capsaicin has considerable therapeutic development potential in inflammation, neurotoxicity and tissue degeneration and may be beneficial in neuroprotection and in pathologies associated with the cardiovascular and central nervous systems.
View Full Article  


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms