Signaling by Wnt glycoprotein regulates various developmental processes. Recent studies revealed that several lipids and their elaborate regulation have crucial functions in Wnt signal activation during development. Lipids and lipid-related proteins are involved in (1) modification of Wnt glycoprotein ligands for its secretion and activation, (2) selective activation of Wnt signaling branches, (3) endocytosis of Wnt protein complexes for signal activation, and (4) formation and activation of Wnt signalosome. Dysregulation of these processes causes defects in embryogenesis and in numerous developmental processes. Here we review recent efforts to elucidate the functions of lipid in Wnt signaling during development, and highlight remaining questions that need to be addressed in the future studies.
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