Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Trends in Cell & Molecular Biology   Volumes    Volume 9 
Abstract
Vertebrate RECK in development and disease
Jessica A. Willson, Sashko Damjanovski
Pages: 95 - 105
Number of pages: 11
Trends in Cell & Molecular Biology
Volume 9 

Copyright © 2014 Research Trends. All rights reserved

ABSTRACT
 
Extracellular matrix (ECM) remodeling is a tightly controlled event that requires a proper balance between matrix metalloproteinases (MMPs) and their endogenous inhibitors. Since aberrant MMP activity is associated with developmental defects and cancer progression, the presence of MMP inhibitors is crucial during these processes to ensure controlled cell migration. Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is a novel MMP inhibitor that was originally discovered as a tumor suppressor protein due to its ability to decrease invasiveness when re-expressed in tumor-derived cell lines. Not only is RECK important for tumor suppression, but it also plays crucial developmental roles. RECK has been implicated in regulating angiogenesis, neurogenesis, and limb patterning during embryogenesis. Although RECK was first identified as an MMP inhibitor, emerging evidence suggests that it plays an important role in regulating intracellular signaling pathways such as Notch, STAT3, and Wnt7a signaling pathways.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms