ABSTRACT The convenience of the use of either a convergent or a stepwise approach for the preparation of nucleopeptides is discussed. We describe the solid-phase synthesis of nucleopeptides H-Ser(p5´T)-Gly-Leu-NH2, Piv-Ser(p5´ACGT)-Gly-Leu-NH2 and Phac-Ser(p3´CATCAT)-Gly-Asp-OH with a phosphate diester linkage between the peptide and the oligonucleotide, and the preparation of an analogue, Ac-Ser-Gly-Asp-NH-p5´T, with an acylphosphoramidate union.
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