ABSTRACT This article reviews the area of reactive species derived from molecular dioxygen and the processes by which animal systems ameliorate the deleterious effects of the generation of these species. Individual topics which are contained in this review are: (i) identification of the major types of toxic reactive oxygen species which are encountered in animal tissues; (ii) the damage that such species can cause; (iii) endogenous antioxidants of animal tissues; (iv) enzymes involved in detoxification of reactive oxygen species; (v) the specific ways in which different tissues effect detoxification; and (vi) the effects of normal and abnormal physiological changes in tissues in relation to detoxification processes.
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