Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Biochemical Research   Volumes    Volume 11  Issue 1
Keep them breathing - Protein quality control networks as watchdogs of mitochondrial integrity
Tom Bender, Wolfgang Voos
Pages: 99 - 110
Number of pages: 12
Current Topics in Biochemical Research
Volume 11  Issue 1

Copyright © 2009 Research Trends. All rights reserved

Mitochondria are essential constituents of eukaryotic cells, and their numerous functions include cellular respiration and generation of ATP. To maintain these mitochondrial func­tions, it is crucial to secure protein homeosta­sis, i.e. maintenance of a functional protein population. This task is executed through a sophisti­cated protein quality control network of molecular chaperones and proteases. In par­ticular, the generation of reactive oxygen species at respiratory chain complexes is a major threat to the integrity of the organelle. This requires the removal of damaged pro­teins by the Pim1/Lon protease. As compo­nents of the protein quality control machinery are encoded by nuclear genes, mitochondrial stress conditions need to be signaled to the nucleus, a process that requires the action of another mitochondrial protease, ClpP.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms