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Current Topics in Pharmacology   Volumes    Volume 13  Issue 1
Lactoferrin stimulates cell growth and survival in neuronal cells via activation of integrin-dependent signals
Toshiaki Ishii
Pages: 67 - 73
Number of pages: 7
Current Topics in Pharmacology
Volume 13  Issue 1

Copyright © 2009 Research Trends. All rights reserved

Lactoferrin (Lf) is an iron-binding secretory protein present in breast milk, mucosal secretions, and the secondary granules of neutrophils, and its multiple functions include anti-microbial, immunomodulatory and anti-inflammatory activities. Lf is also present in cerebrospinal fluid, neurons and glial cells, and it accumulates in the brains of individuals with neurodegenerative disorders and elderly individuals. Lf activates integrin-dependent intracellular signals by binding to cell membrane-associated proteoglycans. Lf stimulates anchorage-independent growth and survival in neuronal cells. However, the role of  Lf in neuronal cells is not fully understood. This article discusses the effect of Lf on neuronal cells,  its  signaling pathway and also  the role of endogenous Lf in neuronal disorders. Buy this Article


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