An important problem in chemical reaction engineering is the establishment of an adequate kinetic model and the precise estimation of the involved parameters. Nowadays, experimental design techniques are recognized as the most useful to these purposes. Investigators, however, often face to difficulties in the application of such methodology due to the particularities of the reaction system and laboratory reactor. This paper summarizes the most frequent problems encountered by researches in chemical kinetics and suggests possible solutions, which are illustrated with two examples: the dehydration of 2-propanol from the gas phase in a fixed bed catalytic reactor and the isomerization of maleic acid to fumaric acid in a continuous stirred tank reactor.