Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Pharmacology   Volumes    Volume 9  Issue 1
Wound healing by immature astrocytes and axonal regeneration
Takeshi Nishio
Pages: 1 - 16
Number of pages: 16
Current Topics in Pharmacology
Volume 9  Issue 1

Copyright © 2005 Research Trends. All rights reserved

Following injury, severed axons in the adult mammalian central nervous system (CNS) fail to regenerate beyond the lesion site. However, adult CNS neurons still have an intrinsic capability to regenerate axons if provided with an appropriate environment.  Injury to the CNS induces tissue damage, which is repaired through wound healing processes that finally result in forming barriers to regeneration. Elimination of these barriers promotes axonal regeneration with only partial functional recovery. This indicates that eliminating the barriers is insufficient to promote robust axonal regeneration. In contrast to the adult CNS, robust axonal regeneration can occur beyond the lesion site in young animals, in which immature astrocytes play a key role to facilitate axonal regeneration.  Thus, immature astrocytes appear to reconstruct the lost guidance cues at the lesion site in young animals. On the other hand, transplantation of Schwann cells, olfactory ensheathing cells, marrow stromal cells, astrocytes, fetal CNS tissue, and peripheral nerve grafts has been shown to induce axonal regeneration in adult CNS. However, accurate reconstruction of neural connections is essential for significant functional recovery, which requires the reconstruction of proper guidance cues at the lesion site. Within these strategies, transplantation of immature astrocytes or fetal CNS tissue is most likely to reconstruct the proper guidance cues at the lesion site and to induce the robust axonal regeneration with remarkable functional recovery. 
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms