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Current Topics in Pharmacology   Volumes    Volume 9  Issue 1
Effect of amitriptyline on adenosine release in response to veratridine depolarization in rat prefrontal cortex
Krystyna Gołembiowska, Anna Dziubina
Pages: 127 - 132
Number of pages: 6
Current Topics in Pharmacology
Volume 9  Issue 1

Copyright © 2005 Research Trends. All rights reserved


The effect of local and peripheral administration of amitriptyline (AMI) on the veratridine (10 μM) -evoked adenosine release in rat prefrontal cortex of conscious rats was examined using an in vivo microdialysis. AMI (10, 50 and 100 μM), given acutely or repeatedly for 14 days in a dose of 10 mg/kg, decreased the veratridine-evoked adenosine release. A similar effect was produced by desipramine (DMI, 0.05, 10, 50 and 100 μM), citalopram (CIT, 50 and 100 μM) and venlafaxine (VFX, 1,10 and 50 μM). Antidepressant drugs, with the exception of AMI given chronically, did not affect the basal extracellular adenosine level. The obtained results indicate that antidepressant drugs may influence depolarization-induced adenosine release. It is likely that this effect is mediated by the blockde of Na+ - and Ca2+- channels caused by these drugs; however, only their high concentrations during chronic administration seem to affect adenosine uptake causing an increase in extracellular adenosine level. The interaction between antidepressants and ionic channels may be relevant for their therapeutic effect in the treatment of depressive disorders.

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