Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Trends in Cell & Molecular Biology   Volumes    Volume 3 
Odorants govern selective activation of the human olfactory receptor OR17-210 (OR1E3P) differentially coupled to G-proteins
Olivier Clot-Faybesse, Anne Tromelin, Maryse Gremigni, Thierry Thomas-Danguin, Aurélie Seassau, Valéry Matarazzo, Peter Lai, Chiquito Crasto, Elisabeth Guichard, Patrick Etiévant, Catherine Ronin
Pages: 85 - 101
Number of pages: 17
Trends in Cell & Molecular Biology
Volume 3 

Copyright © 2008 Research Trends. All rights reserved

The olfactory system can screen thousands of volatile compounds through olfactory receptors. Most of these G-coupled receptors are orphaned, and the molecular basis of the early combinatorial coding of odors is yet to be elucidated. Such an assessment is critical for humans. In this report, we have focused on the odorant profile of OR 17-210 (OR1E3P), a human chemoreceptor binding an odorant binding protein and responsive to cyclic ketones with carbon chain lengths of 8 to 13 carbon atoms. Efficacy of this OR binding with ketones has been estimated based on the abundant expression of this receptor in the baculovirus/  insect system. Computational derived models of this receptor have also been recently published.  OR17-210-excitatory ligands displayed monophasic or biphasic dose response curves; such structure-activity relationships are indicative of two groups of odorants that are structurally different. Odorant-binding efficacy could be further related to the G-protein coupling status of the receptor based on the co-expression of the OR with or without a Gα16 protein. Accordingly, it has been proposed that structurally related agonists may differentially recruite OR 17-210 binding sites as a function of their concentration and transduce post-binding signaling through preferred G-protein coupling.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms